Development of a tertiary lymphoid structure-based prognostic model for breast cancer: integrating single-cell sequencing and machine learning to enhance patient outcomes.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: Breast cancer, a highly prevalent global cancer, poses significant challenges, especially in advanced stages. Prognostic models are crucial to enhance patient outcomes. Tertiary lymphoid structures (TLS) within the tumor microenvironment have been associated with better prognostic outcomes.

Authors

  • Xiaonan Zhang
    Department of Natural Language Processcing, Baidu International Technology (Shenzhen) Co., Ltd, Shenzhen 518000, China.
  • Li Li
    Department of Gastric Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
  • Xiaoyu Shi
    Department of Pathophysiology, Bengbu Medical University, Bengbu, Anhui, China.
  • Yunxia Zhao
    Department of Pathophysiology, Bengbu Medical University, Longzihu, Bengbu, Anhui, China.
  • Zhaogen Cai
    Department of Pathology, Bengbu Medical University, Longzihu, Bengbu, Anhui, China.
  • Ni Ni
    School of Clinical Medicine, Bengbu Medical University, Bengbu, Anhui, China.
  • Di Yang
    Clinical and Research Center of AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Zixin Meng
    School of Clinical Medicine, Bengbu Medical University, Longzihu, Bengbu, Anhui, China.
  • Xu Gao
    National Research Base of Intelligent Manufacturing Service, School of Management Science and Engineering, Chongqing Technology and Business University, Chongqing, 400067, China; Chongqing Water Group Co. Ltd., Chongqing, 400042, China. Electronic address: hughgao@outlook.com.
  • Li Huang
    National Research Center for Resettlement (NRCR), Hohai University, 1 Xikang Road, Nanjing 210098, China. lily8214@hhu.edu.cn.
  • Tao Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.