The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis.

Journal: Biology direct
PMID: 39780278

Abstract

BACKGROUND: Endothelial cells are integral components of the tumor microenvironment and play a multifaceted role in tumor immunotherapy. Targeting endothelial cells and related signaling pathways can improve the effectiveness of immunotherapy by normalizing tumor blood vessels and promoting immune cell infiltration. However, to date, there have been no comprehensive studies analyzing the role of endothelial cells in the diagnosis and treatment of prostate adenocarcinoma (PRAD).

Authors

  • Gujun Cong
    Clinical Laboratory Center, Affiliated Mental Health Center of Nantong University (Nantong Fourth People's Hospital, Nantong, China.
  • Jingjing Shao
    Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University & Nantong Tumor Hospital, Nantong, China.
  • Feng Xiao
    Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
  • HaiXia Zhu
    Cancer Research Centre Nantong, Affiliated Tumor Hospital of Nantong University, Nantong, China.
  • Peipei Kang
    Department of Anesthesiology, Affiliated Tumor Hospital of Nantong University & Nantong Tumor Hospital, Nantong, China.

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