Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, multicentre longitudinal study.

Journal: BMJ open
PMID: 39773784

Abstract

INTRODUCTION: Heart failure (HF) is a complex clinical syndrome. Accurate risk stratification and early diagnosis of HF are challenging as its signs and symptoms are non-specific. We propose to address this global challenge by developing the STRATIFYHF artificial intelligence-driven decision support system (DSS), which uses novel analytical methods in determining the risk, diagnosis and prognosis of HF. The primary aim of the present study is to collect prospective clinical data to validate the STRATIFYHF DSS (in terms of diagnostic accuracy, sensitivity and specificity) as a tool to predict the risk, diagnosis and progression of HF. The secondary outcomes are the demographic and clinical predictors of risk, diagnosis and progression of HF.

Authors

  • Sarah Jane Charman
    Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.
  • Nduka C Okwose
    Centre for Health and Life Sciences, Coventry University - Coventry Campus, Coventry, UK.
  • Amy Groenewegen
    Department of General Practice, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Annamaria Del Franco
    University Hospital Careggi, Firenze, Italy.
  • Maria Tafelmeier
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
  • Andrej Preveden
    University of Novi Sad Faculty of Medicine, Novi Sad, Serbia.
  • Cristina Garcia Sebastian
    Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Amy S Fuller
    Centre for Health and Life Sciences, Coventry University - Coventry Campus, Coventry, UK.
  • David Sinclair
    Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK.
  • Duncan Edwards
    Department of Public Health and Primary Care, Primary Care Unit, University of Cambridge, Cambridge, UK.
  • Anne Pauline Nelissen
    Department of General Practice, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Petros Malitas
    PKNM Solutions Sàrl, Colombier, Vaud, Switzerland.
  • Aikaterini Zisaki
    PKNM Solutions Sàrl, Colombier, Vaud, Switzerland.
  • Josep Darba
    Department of Economics, University of Barcelona, Barcelona, Spain.
  • Zoran Bosnić
    Faculty of Computer and Information Science, University of Ljubljana, Večna pot 113, Ljubljana, Slovenia.
  • Petar Vracar
    University of Ljubljana Faculty of Computer and Information Science, Ljubljana, Slovenia.
  • Fausto Barlocco
    Department of Experimental and Clinical Medicine, University of Florence and Cardiomyopathies Unit, Azienda Ospedaliera Careggi, Florence, Italy.
  • Dimitris Fotiadis
    Department of Biomedical Research, Foundation for Research and Technology - Hellas, Hellas, Greece.
  • Prithwish Banerjee
    Department of Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
  • Guy A MacGowan
    Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
  • Oscar Fernandez
    Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
  • José Zamorano
    Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Marta Jiménez-Blanco Bravo
    Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Lars S Maier
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
  • Iacopo Olivotto
    Division of Cardiology, University of Florence, Florence.
  • Frans H Rutten
    Department of General Practice, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Jonathan Mant
    Department of Public Health and Primary Care, Primary Care Unit, University of Cambridge, Cambridge, UK.
  • Lazar Velicki
  • Petar M Seferović
    University of Belgrade Faculty of Medicine, Belgrade, Serbia.
  • Nenad Filipovic
  • Djordje G Jakovljevic
    Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK and with the Faculty of Health and Life Sciences, Coventry University, Coventry, UK.

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