Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study.

Journal: Molecular medicine (Cambridge, Mass.)
PMID: 39773329

Abstract

BACKGROUND: Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, and programmed cell death (PCD) is increasingly recognized as a potential target in cancer therapy and prognosis. However, a PCD-based predictive model for serous ovarian carcinoma (SOC) is lacking. In the present study, we aimed to establish a cell death index (CDI)-based model using PCD-related genes.

Authors

  • Lele Ye
    Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Chunhao Long
    School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Binbing Xu
    First Clinical College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Xuyang Yao
    First Clinical College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Jiaye Yu
    Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research and Precision Medicine, Wenzhou Key Laboratory of Cancer-Related Pathogens and Immunity, Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Institute of Tropical Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yunhui Luo
    Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research and Precision Medicine, Wenzhou Key Laboratory of Cancer-Related Pathogens and Immunity, Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Institute of Tropical Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yuan Xu
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, China.
  • Zhuofeng Jiang
    School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Zekai Nian
    Second Clinical College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yawen Zheng
    Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education) of the Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Yaoyao Cai
    Department of Obstetrics, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Xiangyang Xue
  • Gangqiang Guo
    Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. gangqiangg@wmu.edu.cn.

Keywords

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