Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation.

Journal: Clinical epigenetics
PMID: 39962544

Abstract

BACKGROUND: The changes in DNA methylation patterns may reflect both physical and mental well-being, the latter being a relatively unexplored avenue in terms of clinical utility for psychiatric disorders. In this study, our objective was to identify the methylation-based biomarkers for anxiety disorders and subsequently validate their reliability.

Authors

  • Yoonsung Kwon
    Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
  • Asta Blazyte
    Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
  • Yeonsu Jeon
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Yeo Jin Kim
    Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
  • Kyungwhan An
    Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
  • Sungwon Jeon
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Hyojung Ryu
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Dong-Hyun Shin
    Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
  • Jihye Ahn
    Department of Optometry, College of Energy and Biotechnology, Seoul National University of Science and Technology, Seoul, Republic of Korea.
  • Hyojin Um
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Younghui Kang
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Hyebin Bak
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Byoung-Chul Kim
    Clinomics Inc, Osong, 66819, Republic of Korea.
  • Semin Lee
    Department of Biomedical Engineering, School of Life Sciences, UNIST, Ulsan, Republic of Korea. seminlee@unist.ac.kr.
  • Hyung-Tae Jung
    Department of Psychiatry, Ulsan Medical Center, Ulsan, 44686, Republic of Korea. lukie004@naver.com.
  • Eun-Seok Shin
    Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
  • Jong Bhak
    Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. jongbhak@genomics.org.

Keywords

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