Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning.

Journal: International immunopharmacology
PMID: 39929099

Abstract

BACKGROUND: Spinal cord injury (SCI) is a severe condition affecting the central nervous system. It is marked by a high disability rate and potential for death. Research has demonstrated that programmed cell death (PCD) plays a significant role in the death of neuronal cells during SCI. The objective of our work was to illustrate the significant contribution of PCD genes in the progression of SCI.

Authors

  • Yongjie Wang
    Department of Epidemiology and Medical Statistics School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China.
  • Zilin Zhang
    College of Agricultural Engineering, Shanxi Agricultural University, Jinzhong, 030801, China.
  • Weiquan Gong
    Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, Changchun 130021, China.
  • Zhenshan Lv
    Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, Changchun 130021, China.
  • Jinwei Qi
  • Song Han
    Department of Anorectal Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong 266035, China.
  • Boyuan Liu
    School of Pharmaceutical Sciences, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
  • Aijun Song
    Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, Changchun 130021, China.
  • Zongyuan Yang
    Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, Changchun 130021, China.
  • Longfei Duan
    Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, Changchun 130021, China.
  • Shaokun Zhang
    Physical Education Institute, East China Jiaotong University, Nanchang, Jiangxi 330000, China.

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