AIMC Topic: Spinal Cord Injuries

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Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury.

Journal of molecular neuroscience : MN
Spinal cord injury (SCI), a traumatic type of central nervous system injury, is closely associated with neuronal apoptosis. However, the specific biomarkers and regulatory mechanisms of neuronal apoptosis in SCI patients remain unclear. In this study...

Using multiple machine learning algorithms to predict spinal cord injury in patients with cervical spondylosis: a multicenter study.

Scientific reports
Degenerative cervical spondylosis, a chronic and progressive condition, has a considerable impact on global health. Spinal cord injury, a severe sequela of this disease, can result from this disease. Machine learning (ML) has emerged as a valuable to...

Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury.

BMC medicine
BACKGROUND: Successfully completing clinical trials for rare and heterogeneous disorders, like spinal cord injuries (SCI), remains challenging, thereby reducing the ability to test and translate promising preclinical findings. We propose synthetic co...

Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.

Journal of neuroengineering and rehabilitation
The restoration of standing and walking after spinal cord injury (SCI) remains a top priority for individuals with paraplegia. Despite significant advancements in neuromodulation techniques, challenges such as limited selectivity and inconsistent out...

Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury.

Molecular medicine reports
Spinal cord injury (SCI) represents a notable global health challenge, with neuropathic pain (NP) being a common complication that intensifies patient suffering. Existing research tends to overlook the temporal aspects of NP and fails to offer target...

Cortical modulation through robotic gait training with motor imagery brain-computer interface enhances bladder function in individuals with spinal cord injury.

Scientific reports
Neurogenic bladder (NB) dysfunction in individuals with complete spinal cord injury (SCI) is a condition that significantly affects quality of life. Despite the prevalence of interventions, there is a substantial gap in effective treatments for this ...

Nanoparticle-Mediated Regulation of Intracellular Ferric Ions to Induce Motor Neuron Differentiation for Spinal Cord Injury Repair.

ACS nano
Stem cell therapy is a prospective approach to the treatment of spinal cord injury (SCI), which features grievous harm of motor and sensory functions. However, the proportion of motor neurons spontaneously differentiated from neural stem cells (NSCs)...

Human iPSC-derived spinal neural progenitors enhance sensorimotor recovery in spinal cord-injured NOD-SCID mice via differentiation and microenvironment regulation.

Cell death & disease
Spinal cord injury (SCI) remains a significant clinical challenge and poses a dramatic threat to the life quality of patients due to limited neural regeneration and detrimental post-injury alternations in tissue microenvironment. We developed a thera...

Gait training using powered robotic exoskeleton for a person with spinal cord injury: a case report.

Spinal cord series and cases
INTRODUCTION: Robotic Exoskeleton-assisted gait training is an emerging approach in spinal cord injury (SCI) rehabilitation. This case report evaluates the effectiveness of Powered-Robotic exoskeleton-based gait training in an individual with chronic...

Identification and experimental validation of BMX as a crucial PANoptosis‑related gene for immune response in Spinal Cord Injury.

PloS one
Spinal cord injury (SCI) is a debilitating neurological condition that severely impacts motor, sensory, and autonomic functions, leading to significant challenges in patient quality of life and imposing substantial economic burdens on society. PANopt...