Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Journal: Journal of colloid and interface science
PMID: 40147372

Abstract

Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, achieved through the fabrication of a novel colloidal microrobot with unique functional properties. The microrobot is a Janus colloidal sphere with one hemisphere coated with heparin-mimicking polymers and the other with gold. This structure endows the microrobot with self-propulsion capabilities, powered by biocompatible near-infrared (NIR) irradiation, without the need for chemical fuel. The heparin-mimicking polymers not only prevent blood clotting but also promote endothelial cell growth while inhibiting the proliferation of smooth muscle cells. Additionally, the self-propulsion feature allows the microrobot to travel long distances within blood vessels and precisely target sites for anticoagulation. Our work validates an approach for the production of biofunctionalized microrobots, which introduces a novel avenue for anticoagulation application through the development of innovative biofunctionalized colloidal devices.

Authors

  • Huanhuan Wang
    Institute of Medical Information Security, Xuzhou Medical University, Xuzhou, China.
  • Huaguang Wang
    College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. Electronic address: hgwang@suda.edu.cn.
  • Xiaoli Liu
    Neurology Department, Zhejiang Hospital, Zhejiang 310013, China.
  • Zexin Zhang
    College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China; Institute for Advanced Study, Center for Soft Condensed Matter Physics and Interdisciplinary Research, School of Physical Science and Technology, Soochow University, Suzhou 215006, China. Electronic address: zhangzx@suda.edu.cn.

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