AIMC Topic: Myocytes, Smooth Muscle

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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal of translational medicine May 9, 2025
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
Male Middle Aged Case-Control Studies Cell Hypoxia Myocytes, Smooth Muscle ROC Curve Coronary Artery Disease Humans Biomarkers Guanine Nucleotide Exchange Factors Female Aged Foam Cells
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Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Journal of colloid and interface science Mar 19, 2025
Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, ...
Myocytes, Smooth Muscle Colloids Heparin Anticoagulants Cell Proliferation Humans Polymers Blood Coagulation Particle Size Surface Properties Robotics Gold Human Umbilical Vein Endothelial Cells
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Screening of CAD-related secretory genes associated with type II diabetes based on comprehensive bioinformatics analysis and machine learning.

BMC cardiovascular disorders Nov 5, 2024
BACKGROUND: Type II diabetes mellitus (T2DM) is strongly linked with a heightened risk of coronary artery disease (CAD). Exploring biological targets common to T2DM and CAD is essential for CAD intervention strategies.
Middle Aged Gene Expression Profiling Transcriptome Diabetes Mellitus, Type 2 Female Aged Male Computational Biology Databases, Genetic Coronary Artery Disease Myocytes, Cardiac Single-Cell Analysis Gene Regulatory Networks Genetic Predisposition to Disease Humans Machine Learning Myocytes, Smooth Muscle Fibroblast Growth Factor 7
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Soft robotic constrictor for in vitro modeling of dynamic tissue compression.

Scientific reports Aug 13, 2021
Here we present a microengineered soft-robotic in vitro platform developed by integrating a pneumatically regulated novel elastomeric actuator with primary culture of human cells. This system is capable of generating dynamic bending motion akin to th...
Robotics Tissue Engineering Myocytes, Smooth Muscle Endothelial Cells Compressive Strength In Vitro Techniques Neoplasm Invasiveness Fibroblasts Humans
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Super-Soft and Super-Elastic DNA Robot with Magnetically Driven Navigational Locomotion for Cell Delivery in Confined Space.

Angewandte Chemie (International ed. in English) Dec 23, 2019
Soft organisms such as earthworms can access confined, narrow spaces, inspiring scientists to fabricate soft robots for in vivo manipulation of cells or tissues and minimally invasive surgery. We report a super-soft and super-elastic magnetic DNA hyd...
DNA Magnetics Porosity Gene Transfer Techniques Microscopy, Fluorescence Hydrogels Mice Animals Shear Strength Myocytes, Smooth Muscle Nucleic Acid Amplification Techniques Drug Carriers Doxorubicin Robotics
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Sorghum Fermented by NK Enhances Inhibition of Vascular Inflammation in TNF-α-stimulated Human Aortic Smooth Muscle Cells.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition Jun 25, 2019
Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory effects are unknown. Therefore, this study inve...
Sorghum Inflammation Humans Tumor Necrosis Factor-alpha Aspergillus oryzae Cells, Cultured Myocytes, Smooth Muscle
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Purinones Saphenous Vein Endothelial Cells Receptors, G-Protein-Coupled Thiourea Aminosalicylic Acids rho-Associated Kinases Muscle, Smooth, Vascular Actin Cytoskeleton HEK293 Cells Cell Movement Humans rhoA GTP-Binding Protein Naphthols Myocytes, Smooth Muscle Cell Proliferation Thiazolidines Dose-Response Relationship, Drug Time Factors Signal Transduction Hydrazones
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Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle.

American journal of physiology. Lung cellular and molecular physiology Jul 1, 2025
Intracellular calcium (Ca) release via phospholipase C (PLC) following G-protein-coupled receptor (GPCR) activation is typically linked to membrane depolarization and airway smooth muscle (ASM) contraction. However, recent findings show that bitter t...
Animals Receptors, G-Protein-Coupled Calcium Myocytes, Smooth Muscle Humans Chloroquine Taste Receptors, Type 2 Histamine Flufenamic Acid Respiratory System Calcium Signaling Muscle, Smooth
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