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Blood Coagulation

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Heparin in sepsis: current clinical findings and possible mechanisms.

Frontiers in immunology
Sepsis is a clinical syndrome resulting from the interaction between coagulation, inflammation, immunity and other systems. Coagulation activation is an initial factor for sepsis to develop into multiple organ dysfunction. Therefore, anticoagulant th...

Coagulo-Net: Enhancing the mathematical modeling of blood coagulation using physics-informed neural networks.

Neural networks : the official journal of the International Neural Network Society
Blood coagulation, which involves a group of complex biochemical reactions, is a crucial step in hemostasis to stop bleeding at the injury site of a blood vessel. Coagulation abnormalities, such as hypercoagulation and hypocoagulation, could either c...

Prediction model of gastrointestinal tumor malignancy based on coagulation indicators such as TEG and neural networks.

Frontiers in immunology
OBJECTIVES: Accurate determination of gastrointestinal tumor malignancy is a crucial focus of clinical research. Constructing coagulation index models using big data is feasible to achieve this goal. This study builds various prediction models throug...

Prediction of clinical deterioration within one year in chronic obstructive pulmonary disease using the systemic coagulation-inflammation index: a retrospective study employing multiple machine learning method.

PeerJ
BACKGROUND: Inflammatory response and the coagulation system are pivotal in the pathogenesis of clinical deterioration in chronic obstructive pulmonary disease (COPD), prompting us to hypothesize that the systemic coagulation-inflammation (SCI) index...

Applying artificial intelligence to uncover the genetic landscape of coagulation factors.

Journal of thrombosis and haemostasis : JTH
Artificial intelligence (AI) is rapidly advancing our ability to identify and interpret genetic variants associated with coagulation factor deficiencies. This review introduces AI, with a specific focus on machine learning (ML) methods, and examines ...

Systemic coagulation-inflammation index in the prediction of ISR in patients undergoing drug-eluting stents implant: A retrospective study based on multiple machine learning methods.

International journal of cardiology
BACKGROUND: The Systemic Coagulation-Inflammation index (SCI) is an innovative hematological metric that accurately reflects both coagulopathic and inflammatory dynamics. In this paper, the objective of this paper is to explain the prognostic impact ...

Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Journal of colloid and interface science
Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, ...

State-of-the-art for automated machine learning predicts outcomes in poor-grade aneurysmal subarachnoid hemorrhage using routinely measured laboratory & radiological parameters: coagulation parameters and liver function as key prognosticators.

Neurosurgical review
The objective of this study was to develop and evaluate automated machine learning (aML) models for predicting short-term (1-month) and medium-term (3-month) functional outcomes [Modified Rankin Scale (mRS)] in patients suffering from poor-grade aneu...

Rapid Blood Clot Removal via Remote Delamination and Magnetization of Clot Debris.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Micro/nano-scale robotic devices are emerging as a cutting-edge approach for precision intravascular therapies, offering the potential for highly targeted drug delivery. While employing micro/nanorobotics for stroke treatment is a promising strategy ...