Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.

Journal: Lipids in health and disease
PMID: 40089748

Abstract

BACKGROUND: Surrogate insulin resistance (IR) indices are simpler and more practical alternatives to insulin-based IR indicators for clinical use. This study explored the association between surrogate IR indices, including triglyceride-glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist to height ratio (TyG-WHtR), metabolic score for insulin resistance (METS-IR), and the triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, and coronary artery disease (CAD) in patients with type 2 diabetes (T2D).

Authors

  • Amirhossein Yadegar
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Mohammadi
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Kiana Seifouri
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Kiavash Mokhtarpour
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Sepideh Yadegar
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ehsan Bahrami Hazaveh
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Arsalan Seyedi
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Soghra Rabizadeh
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Alireza Esteghamati
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Manouchehr Nakhjavani
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. nakhjavanim@tums.ac.ir.

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