Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.

Authors

  • Chao Feng
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Yaobang Wang
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
  • Wuyue Song
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Tao Liu
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Han Mo
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Hui Liu
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Shulin Wu
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Zezu Qin
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Zhenxing Wang
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
  • Yuting Tao
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
  • Liangyu He
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Shaomei Tang
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
  • Yuanliang Xie
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
  • Qiuyan Wang
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
  • Tianyu Li
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.