Gadoxetic acid-enhanced MRI for identifying cholangiocyte phenotype hepatocellular carcinoma by interpretable machine learning: individual application of SHAP.

Journal: BMC cancer
PMID: 40295993

Abstract

PURPOSE: Cholangiocyte phenotype hepatocellular carcinoma (HCC) is highly invasive. This study aims to develop and validate an optimal machine learning model to predict cholangiocyte phenotype HCC based on T1 mapping gadoxetic acid-enhanced MRI and to implement individual applications via the Shapley Additive explanation (SHAP).

Authors

  • Wei Liu
    Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, United States.
  • Zhiping Cai
    College of Computer, National University of Defense Technology, Changsha, China. Electronic address: zpcai@nudt.edu.cn.
  • Yifan Chen
    Adam Smith Business School, University of Glasgow, Scotland, United Kingdom.
  • Xingqun Guan
    Department of Radiology, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, Guangdong Province, 528308, China.
  • Jieying Feng
    Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, Guangdong, China.
  • Haixiong Chen
    Department of Radiology, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, Guangdong Province, 528308, China.
  • Baoliang Guo
    Department of Radiology, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, Guangdong Province, 528308, China.
  • Fusheng Ouyang
    Department of Radiology, The First People's Hospital of Shunde, Foshan, Guangdong, PR China.
  • Chun Luo
    Department of Neurosurgery, Tongji Hospital, Tongji University, Shanghai, China.
  • Rong Zhang
    Internal Medicine - Cardiology Division, UT Southwestern, Dallas, TX, USA.
  • Xinjie Chen
    Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Wuhua District, Kunming, Yunnan Province, China.
  • Xiaohong Li
    College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • Cuiru Zhou
    Department of Radiology, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan), No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan, Guangdong Province, 528308, China.
  • Shaomin Yang
    Xingtan Hospital Affiliated of Southern Medical University Shunde Hospital, No. 222 Xinglong Road, Shunde, China. ysmsin@aliyun.com.
  • Ziwei Liu
    College of Food Science and Engineering, Northwest University, Xi'an 710069, China.
  • Qiugen Hu
    Department of Radiology, Shunde Hospital, Southern Medical University, Foshan, China.

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