Characterization of Brain Abnormalities in Lactational Neurodevelopmental Poly I:C Rat Model of Schizophrenia and Depression Using Machine-Learning and Quantitative MRI.

Journal: Journal of magnetic resonance imaging : JMRI
PMID: 39466009

Abstract

BACKGROUND: A recent neurodevelopmental rat model, utilizing lactational exposure to polyriboinosinic-polyribocytidilic acid (Poly I:C) leads to mimics of behavioral phenotypes resembling schizophrenia-like symptoms in male offspring and depression-like symptoms in female offspring.

Authors

  • Rona Haker
    Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Coral Helft
    Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Emilya Natali Shamir
    School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Moni Shahar
    Intuit, HaHarash St.4, Building C 2nd floor, 4524075, Hod HaSharon, Israel.
  • Hadas Solomon
    Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Noam Omer
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.
  • Tamar Blumenfeld-Katzir
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.
  • Sharon Zlotzover
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.
  • Yael Piontkewitz
    School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Ina Weiner
    Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Noam Ben-Eliezer
    Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.

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