Medication versus globus pallidus internus deep brain stimulation in Parkinson's disease with deep learning video analysis of finger tapping.

Journal: Scientific reports
Published Date: May 21, 2025

Abstract

In advanced Parkinson's disease (PD), considerable number of patients receive deep brain stimulation (DBS) surgery, to alleviate symptoms not readily controlled by medication. However, the differential effects of medication and DBS on improving motor symptoms, especially for DBS targeting the globus pallidus internus (GPi), have not been explored in sufficient detail. We studied the finger tapping (FT) task of the Movement Disorder Society Unified Parkinson's Disease Rating Scale Part 3, to evaluate the improvements in bradykinesia achieved through GPi DBS in patients with PD. In this observational study, videos were recorded during the FT task in four different states for each patient, without and with medication in the preoperative setting, and before and after DBS programming in the postoperative setting. Using a deep learning model, we reconstructed the 2D hand motions into 3D meshes to extract 21 motion parameters that characterize hand bradykinesia. We employed these parameters to predict the FT score using machine learning models. Finally, statistical tests were used to compare motion parameters across four distinct states. A total of 556 videos from 87 patients were collected. The best model predicted the FT score with an accuracy of 0.70, which was on par with human experts. Notably, GPi DBS significantly improved speed and acceleration parameters compared to medication. Our study results indicate that GPi DBS and medication might act through different mechanisms, with GPi DBS more directly influencing neural pathways related to speed control in fine rhythmic hand movements.

Authors

  • Grace Yoojin Lee
    Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Hee Yeon Kwon
    Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
  • Kanggil Park
    Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Sungyang Jo
    From the Departments of Neurology (K.W.P., E.-J.L., S.J., M.J., J.Y.D., D.-W.K., S.J.C.) and Convergence Medicine (J.S.L., J.J., J.-G.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; Electronics and Telecommunications Research Institute (J.S.L.), Gwangju; Promedius Inc (J.J.), Seoul; and Department of Neurology (N.C.), Heavenly Hospital, Goyang, Korea.
  • Jihyun Lee
    SCH Media Labs, Soonchunhyang University, Asan, Chungnam, South Korea.
  • Sangjin Lee
    Department of Cardiovascular Surgery, Spectrum Health Grand Rapids, Grand Rapids, MI, USA.
  • June-Goo Lee
    Biomedical Engineering Research Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
  • Namkug Kim
    Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Sun Ju Chung
    From the Departments of Neurology (K.W.P., E.-J.L., S.J., M.J., J.Y.D., D.-W.K., S.J.C.) and Convergence Medicine (J.S.L., J.J., J.-G.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; Electronics and Telecommunications Research Institute (J.S.L.), Gwangju; Promedius Inc (J.J.), Seoul; and Department of Neurology (N.C.), Heavenly Hospital, Goyang, Korea. sjchung@amc.seoul.kr.

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