Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine learning, and experimental validation.

Journal: Cancer immunology, immunotherapy : CII
Published Date:

Abstract

BACKGROUND: Chaperonin containing TCP1 subunit 5 (CCT5), a vital component of the molecular chaperonin complex, has been implicated in tumorigenesis, cancer stemness maintenance, and therapeutic resistance. Nevertheless, its comprehensive roles in pan-cancer progression, underlying biological functions, and potential as a predictor of immunotherapy response remains poorly understood.

Authors

  • Jiajun Li
    School of Management, Northwestern Polytechnical University, Xi'an 710072, Shaanxi, China.
  • Nuo Xu
    Information Engineering, Guangdong University of Technology, Guangzhou, China.
  • Leyin Hu
    Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, 305000, Zhejiang, China.
  • Jiayue Xu
    Burning Rock Biotech, Guangzhou, China.
  • Yifan Huang
    Department of Orthopedics, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
  • Deqi Wang
    Department of Gastroenterology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
  • Feng Chen
    Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Yi Wang
    Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Jiani Jiang
    Department of Gastroenterology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
  • Yanggang Hong
    The Second School of Clinical Medicine, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. sun160414@icloud.com.
  • Huajun Ye
    Department of Gastroenterology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. yehuajun2020@163.com.