Histopathologic deep learning model for predicting tumor response to hepatic arterial infusion chemotherapy plus TKIs and ICIs in large hepatocellular carcinoma.

Journal: Cancer imaging : the official publication of the International Cancer Imaging Society
Published Date: Jun 6, 2025

Abstract

BACKGROUND: While triplet therapy (HTI), which combines hepatic arterial infusion chemotherapy (HAIC) with tyrosine kinase inhibitors and immune checkpoint inhibitors, is widely used in the treatment of large hepatocellular carcinoma (HCC), there are few reports about its efficacy versus HAIC, and no reliable methods are available for promptly predicting HTI response.

Authors

  • Chunyu Lin
    State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Department of Liver Tumor Center, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhouda Road, Baiyun District, Guangzhou, 510515, China.
  • Yong Ren
    Artificial Intelligence Innovation Center, Research Institute of Tsinghua, Pearl River Delta, Guangzhou, China.
  • Yu Huang
    School of Data Science and Software Engineering, Qingdao University, Qingdao 266021, China.
  • Shuqi Li
    School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
  • Jing Zhang
    MOEMIL Laboratory, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu, China.
  • Shuai Kang
    Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Shurong Li
    Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
  • Changxuan You
    Department of Oncology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhouda Road, Baiyun District, Guangzhou, Guangdong, 510515, China. ycx6026@126.com.
  • Qinghua Cao
    Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Fang Liu
    The First Clinical Medical College of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.

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