A Deep Learning-Derived Transdiagnostic Signature Indexing Hypoarousal and Impulse Control: Implications for Treatment Prediction in Psychiatric Disorders.

Journal: Biological psychiatry. Cognitive neuroscience and neuroimaging
Published Date: Aug 13, 2024

Abstract

BACKGROUND: Psychiatric disorders are traditionally classified within diagnostic categories, but this approach has limitations. The Research Domain Criteria (RDoC) constitute a research classification system for psychiatric disorders based on dimensions within domains that cut across these psychiatric diagnoses. The overall aim of RDoC is to better understand mental illness in terms of dysfunction in fundamental neurobiological and behavioral systems, leading to better diagnosis, prevention, and treatment.

Authors

  • Hannah Meijs
    Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands. Electronic address: hannah@brainclinics.com.
  • Jurjen J Luykx
    Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
  • Nikita van der Vinne
    Synaeda Research, Drachten, the Netherlands.
  • Rien Breteler
    Department of Clinical Psychology, Faculty of Social Sciences, Radboud University, Nijmegen, the Netherlands.
  • Evian Gordon
    Brain Resource Ltd., San Francisco, California.
  • Alexander T Sack
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
  • Hanneke van Dijk
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands; Synaeda Research, Drachten, the Netherlands.
  • Martijn Arns
    Research Institute Brainclinics, Nijmegen & Dept. of Experimental Psychology, Utrecht University, Utrecht, The Netherlands.

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