Development of a patient reported outcomes based machine learning model to predict recurrences in head and neck cancer.

Journal: Oral oncology
Published Date: Apr 19, 2025

Abstract

INTRODUCTION: Recurrence rates among Head and Neck Cancer (HNC) patients are high, with earlier detection associated with improved survival. Patient-reported outcomes (PROs) have increasingly been found to predict patient care needs. Here, we examine whether PROs specific to HNC patients or general can predict disease progression using Machine Learning (ML) algorithms.

Authors

  • Christopher M K L Yao
    Department of Otolaryngology-Head & Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Katrina Hueniken
    Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Shao Hui Huang
  • Geoffrey Liu
    Medical Oncology and Medical Biophysics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Scott Bratman
    Princess Margaret Cancer Center- University of Toronto, Department of Radiation Oncology, Toronto, Ontario, Canada.
  • Andrew Hope
    Radiation Oncology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada.
  • Andrew McPartlin
    Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Jillian C Tsai
    Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
  • Sharon Tzelnik
    Department of Otolaryngology - Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • David Goldstein
    Department of Otolaryngology - Head and Neck Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Ali Hosni
    Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, Canada.
  • Timothy C Y Chan
    Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario M5S 3G8, Canada and Techna Institute for the Advancement of Technology for Health, 124 - 100 College Street, Toronto, Ontario M5G 1P5, Canada.
  • John R de Almeida
    Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada.

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