Artificial intelligence-driven microRNA signature for early detection of gastric cancer: discovery and clinical functional exploration.

Journal: British journal of cancer
Published Date: Apr 15, 2025

Abstract

BACKGROUND: Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with late-stage diagnoses frequently leading to poor outcomes. This underscores the need for effective early-stage gastric cancer (ESGC) diagnostics.

Authors

  • Jiachun Lu
    The School of Public Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
  • Yuqi Chen
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, 430070 Wuhan, PR China.
  • Xin Liu
    Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences, Weifang, Shandong, China.
  • Jiayu Wang
    Department of Cardiology, the Second Hospital of Shandong University, 250033 Jinan, Shandong, China.
  • Yuxin He
    Department of Computer Science, Harbin Institute of Technology, Shenzhen, 518055, China.
  • Tongguo Shi
    Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China. shitg@suda.edu.cn.
  • Weichang Chen
    Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China. weichangchen@126.com.
  • Wenying Yan
    Department of Bioinformatics, School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Soochow University, Suzhou 215123, China.

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