Role of Brain Age Gap as a Mediator in the Relationship Between Cognitive Impairment Risk Factors and Cognition.

Journal: Neurology
Published Date:

Abstract

BACKGROUND AND OBJECTIVES: Cerebrovascular disease (CeVD) and cognitive impairment risk factors contribute to cognitive decline, but the role of brain age gap (BAG) in mediating this relationship remains unclear, especially in Southeast Asian populations. This study investigated the influence of cognitive impairment risk factors on cognition and examined how BAG mediates this relationship, particularly in individuals with varying CeVD burden.

Authors

  • Wei Ying Tan
    Saw Swee Hock School of Public Health (WYT, SH), National University of Singapore and National University Health System, Singapore.
  • Xiangyuan Huang
    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System.
  • Jiannan Huang
    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System.
  • Caroline Robert
    Department of Pharmacology, National University of Singapore; and.
  • Jiangbo Cui
    Department of Pharmacology, National University of Singapore; and.
  • Christopher P L H Chen
    Department of Pharmacology, National University of Singapore; and.
  • Saima Hilal
    Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.