Revisiting Abnormalities of Ventricular Depolarization: Redefining Phenotypes and Associated Outcomes Using Tree-Based Dimensionality Reduction.

Journal: Journal of the American Heart Association
Published Date:

Abstract

BACKGROUND: Abnormal ventricular depolarization, evident as a broad QRS complex on an ECG, is traditionally categorized into left bundle-branch block (LBBB) and right bundle-branch block or nonspecific intraventricular conduction delay. This categorization, although physiologically accurate, may fail to capture the nuances of diseases subtypes.

Authors

  • Mehak Gurnani
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Konstantinos Patlatzoglou
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Joseph Barker
  • Derek Bivona
    Department of Biomedical Engineering University of Virginia Charlottesville VA USA.
  • Libor Pastika
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Ewa Sieliwonczyk
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Boroumand Zeidaabadi
    National Heart and Lung Institute, Imperial College London, London, UK.
  • Paolo Inglese
    Istituto Italiano di Tecnologia Genoa Italy.
  • Lara Curran
    MRC Laboratory of Medical Sciences Imperial College London London UK.
  • Ahran D Arnold
    Department of Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Declan O'Regan
    MRC London Institute of Medical Sciences Imperial College London London UK.
  • Zachary Whinnett
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Kenneth C Bilchick
    Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
  • Nicholas S Peters
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Daniel B Kramer
    Richard A. and Susan F. Smith Center for Outcomes Research, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
  • Jonathan W Waks
    Harvard-Thorndike Electrophysiology Institute, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.
  • Arunashis Sau
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Fu Siong Ng
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.