Exploring the link between grandmaternal air pollution exposure and Grandchild's ASD risk: A multigenerational population-based study in California.

Journal: Environment international
Published Date: Jun 1, 2025

Abstract

BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increasing prevalence. While genetics play a strong causal role, among environmental factors, air pollution (AP) exposure in pregnancy and infancy has been strongly endorsed as a risk factor. However, potential multigenerational impacts through the exposure of the grandmother during her pregnancy remain unexplored.

Authors

  • Karl O'Sharkey
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
  • Ting Chow
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
  • Sanjali Mitra
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
  • Laura Thompson
    Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
  • Jason Su
    From Whiterabbit.ai, 3930 Freedom Cir, Santa Clara, CA 95054 (S.P., T.T., B.M., Y.N.T.V., T.M., R.M.H., M.S., N.G., N.Z.D., J.S.); Onsite Women's Health, Westfield, Mass (S.H.); SSM Health, St Louis, Mo (C.M.A.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (R.L.W.).
  • Myles Cockburn
    Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032, USA.
  • Zeyan Liew
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
  • Beate Ritz
    Departments of Epidemiology and Environmental Health, Fileding School of Public Health, University of California, Los Angeles, CA, USA.

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