Fibroblast growth factor 5: a novel biomarker for familial hypercholesterolaemia.

Journal: European heart journal
Published Date: May 14, 2025

Abstract

BACKGROUND AND AIMS: Identification of individuals affected by familial hypercholesterolaemia (FH) is suboptimal when genetic tests are unavailable. Relying only on low-density lipoprotein cholesterol (LDL-C) is challenging as it may not allow distinguishing individuals with FH from hypercholesterolaemic (HC) individuals from the general population. The aim of this study was to determine whether biomarkers associated with cardiovascular disease and/or inflammation identify FH individuals and distinguish them from HC individuals.

Authors

  • Andrea Baragetti
    Department of Pharmacological and Biomolecular Sciences, University of Milan, and I.R.C.C.S MultiMedica, Milan, Italy.
  • Asiiat S Alieva
    Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis, Almazov National Medical Research Centre, St. Petersburg, The Russian Federation.
  • Liliana Grigore
    Center for the Study of Atherosclerosis, IRCCS MultiMedica, Via Milanese 300, 20099 Sesto San Giovanni, Milan, Italy.
  • Fabio Pellegatta
    Center for the Study of Atherosclerosis, IRCCS MultiMedica, Via Milanese 300, 20099 Sesto San Giovanni, Milan, Italy.
  • Andrea Lupi
    S.I.S.A. Centre for the Study of Atherosclerosis, E. Bassini Hospital, Cinisello Balsamo, Milan, Italy.
  • Chiara Scrimali
    Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo-School of Medicine, Palermo, Italy.
  • Angelo B Cefalù
    Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo-School of Medicine, Palermo, Italy.
  • Barbara A Hutten
    Department of Epidemiology and Data Science, Amsterdam University Medical Center, Location University of Amsterdam, Amsterdam, The Netherlands.
  • Albert Wiegman
    Department of Pediatrics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
  • Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
  • Michiel J Bom
    Department of Cardiology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
  • Nick S Nurmohamed
    Division of Cardiology, The George Washington University School of Medicine, Washington, DC, USA.
  • Olga Reutova
    Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis, Almazov National Medical Research Centre, St. Petersburg, The Russian Federation.
  • Alexandra Konradi
    Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis, Almazov National Medical Research Centre, St. Petersburg, The Russian Federation.
  • Evgeny Shlyakhto
    Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis, Almazov National Medical Research Centre, St. Petersburg, The Russian Federation.
  • Erik S G Stroes
    Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
  • Maurizio Averna
    Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo-School of Medicine, Palermo, Italy.
  • Alberico L Catapano
    Department of Pharmacological and Biomolecular Sciences, University of Milan, and I.R.C.C.S MultiMedica, Milan, Italy.

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