Identification and validation of the nicotine metabolism-related signature of bladder cancer by bioinformatics and machine learning.

Journal: Frontiers in immunology
PMID: 39742262

Abstract

BACKGROUND: Several studies indicate that smoking is one of the major risk factors for bladder cancer. Nicotine and its metabolites, the main components of tobacco, have been found to be strongly linked to the occurrence and progression of bladder cancer. However, the function of nicotine metabolism-related genes (NRGs) in bladder urothelial carcinoma (BLCA) are still unclear.

Authors

  • Yating Zhan
    Department of Blood Transfusion, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Min Weng
    Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Yangyang Guo
    Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Dingfeng Lv
    Department of Blood Transfusion, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Feng Zhao
    Department of Blood Transfusion, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Zejun Yan
    Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Junhui Jiang
    Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  • Yanyi Xiao
    Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
  • Lili Yao
    Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

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