Autophagy-related gene SQSTM1 predicts the prognosis of hepatocellular carcinoma.

Journal: Computers in biology and medicine
Published Date: Jun 1, 2025

Abstract

BACKGROUND: The relationship between autophagy and the progression of hepatocellular carcinoma (HCC) is notably substantial, yet the underlying mechanisms remain incompletely elucidated. Our objective is to construct a predictive model, thereby providing fresh insights into the diagnosis and treatment of HCC. Autophagy's role in HCC progression is recognized, but the exact mechanisms are still unclear. This study seeks to build a predictive model to offer new diagnostic and therapeutic insights for HCC. Through combining bioinformatics and experiments, we aim to clarify autophagy pathways' part in HCC and spot possible treatment targets, thus aiding future HCC research and treatment.

Authors

  • Zhiming Zheng
    Key Laboratory of Mathematics, Informatics and Behavioral Semantics and State Key Laboratory of Software Development Environment, Beihang University, Beijing, China.
  • Haijiong Xu
    The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
  • Lianxiang Luo
    The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, 524023, China. luolianxiang321@gdmu.edu.cn.

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