Pathogenomic fingerprinting to identify associations between tumor morphology and epigenetic states.

Journal: European journal of cancer (Oxford, England : 1990)
Published Date: Apr 14, 2025

Abstract

INTRODUCTION: Measuring the chromatin state of a tumor provides a powerful map of its epigenetic commitments; however, as these are generally bulk measurements, it has not yet been possible to connect changes in chromatin accessibility to the pathological signatures of complex tumors. In parallel, recent advances in computational pathology have enabled the identification of spatial features and immune cells within oral cavity tumors and their microenvironment.

Authors

  • Shayan Monabbati
    Dept. of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • German Corredor
    Universidad Nacional de Colombia, Bogotá D.C, Colombia.
  • Tilak Pathak
    Emory Winship Cancer Institute, Atlanta, GA, USA.
  • Craig Peacock
    Dept. of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Kailin Yang
    Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Shlomo Koyfman
    Cleveland Clinic Foundation, Cleveland, Ohio, USA.
  • Peter Scacheri
    Dept. of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • James Lewis
    Mayo Clinic, AZ, USA.
  • Anant Madabhushi
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
  • Satish E Viswanath
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
  • Berkley Gryder
    Dept. of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: berkley.gryder@case.edu.

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