Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding.

Journal: Frontiers in immunology
Published Date: May 16, 2025

Abstract

INTRODUCTION: Lyme disease (LD) is a tick-borne disease that is a substantial public health burden with estimated about 0.5 million new cases per year in the US and increasing incidence. Differentiating Lyme disease, especially in its early stages, from other febrile illnesses with similar clinical symptoms (look-alike diseases) represents a significant challenge due to the lack of diagnostic tools. Current diagnostic tools based on serology were not specifically developed for differential diagnosis and show limited sensitivity in early LD resulting in high false negative rates.

Authors

  • Tingting Zhang
    Department of Environmental Science and Engineering, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: zhangtt@mail.buct.edu.cn.
  • Laurie Baert
    Department of Immunology, Mayo Clinic, Scottsdale, AZ, United States.
  • Neal W Woodbury
    Center for Innovations in Medicine at the Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States.
  • Laimonas Kelbauskas
    Biodesign Institute, Arizona State University, Tempe, AZ, United States.

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