Single-cell analyses unravel ecosystem dynamics and intercellular crosstalk during gallbladder cancer malignant transformation.

Journal: Hepatology communications
Published Date: Jun 1, 2025

Abstract

BACKGROUND: Gallbladder cancer (GBC) is a rare but aggressive malignancy, often detected late due to early asymptomatic stages. Understanding cellular and molecular changes from normal tissue to high-grade intraepithelial neoplasia (HGIN) and invasive GBC is vital for identifying early biomarkers and therapeutic targets.

Authors

  • Zhaobin He
    Department of Hepatobiliary Surgery, General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China.
  • Jianqiang Cao
    Department of Hepatobiliary Surgery, General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China.
  • Xiqiang Wang
    Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province, China.
  • Shengbiao Yang
    Department of Hepatobiliary Surgery, General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China.
  • Huijie Gao
    Department of Hepatobiliary Surgery, General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, P.R. China.
  • Yongzhe Yu
    Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.
  • Zequn Di
    Department of Hepatobiliary Minimally Invasive Surgery, Shandong University Institute of Endoscopic Minimally Invasive Surgery, Jinan, Shandong Province, China.
  • Cheng Peng
    School of Electrical and Mechanical Engineering, Hefei Technology College, Hefei, China.

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