Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.

Journal: Frontiers in immunology
Published Date: May 22, 2025

Abstract

BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies is slow and limited. The occurrence and progression of cancer are closely associated with metabolic reprogramming. Therefore, this study aimed to identify metabolism-related LCA subtypes through a comprehensive analysis of transcriptomic, mutational, methylation, and single-cell RNA sequencing, in hopes of finding factors which influences the prognosis of LCA.

Authors

  • Dan Zheng
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
  • Xuan Pu
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
  • XuHui Deng
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
  • Cui Liu
    Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
  • Sijun Li
    Department of Geriatric Rehabilitation, Jiangbin Hospital, Nanning, China.

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