Bridging Genomic Research Disparities in Osteoporosis GWAS: Insights for Diverse Populations.

Journal: Current osteoporosis reports
Published Date: May 24, 2025

Abstract

PURPOSE OF REVIEW: Genome-wide association studies (GWAS) have significantly advanced osteoporosis research by identifying genetic loci associated with bone mineral density (BMD) and fracture risk. However, disparities persist due to the underrepresentation of non-European populations, limiting the applicability of polygenic risk scores (PRS). This review examines recent advancements in osteoporosis genetics, highlights existing disparities, and explores strategies for more inclusive research.

Authors

  • Qing Wu
    5 Department of Environmental and Occupational Health, School of Community Health Sciences, University of Nevada , Las Vegas, Nevada.
  • Jingyuan Dai
    Department of Biomedical Informatics (Dr. Qing Wu, Jingyuan Dai), College of Medicine, The Ohio State University, Columbus, OH 43210, United States.
  • Jianing Liu
    Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University, Qinhuangdao, Hebei 066004, P.R.China.
  • Lang Wu
    University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.

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