Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.

Journal: Biology of sex differences
Published Date: May 25, 2025

Abstract

BACKGROUND: The cerebrospinal fluid (CSF) is known to serve as a unique environment for neurodevelopment, with specific proteins secreted by epithelial cells of the choroid plexus (CP) playing crucial roles in cortical development and cell differentiation. Sex-related differences in the brain in early life have been widely identified, but few studies have investigated the neonatal CSF system and associated transcriptional signatures.

Authors

  • Yuxin Sun
    Department of Computer Science.
  • Chenxin Fu
    Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
  • Lifan Gu
    Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
  • Huifang Zhao
    Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China. nuzhenzi_1984@163.com.
  • Yuying Feng
    Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
  • Chao Jin
    Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.

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