ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.

Journal: Journal of ethnopharmacology
Published Date: Apr 16, 2025

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ten years. However, no relevant studies have been done to clarify the pharmacodynamic underpinnings of its regulation of the body's immune system and its related processes.

Authors

  • Yuzhen Liu
    The Department of Obstetrics and Gynecology, Affiliated Hospital of Weifang Medical University, Weifang 261042, People's Republic of China.
  • ZhuXia Wu
    School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, Anhui, China.
  • Chen Gu
    School of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China.
  • Jing Fang
    Department of Information Engineering, Nanchang Hangkong University, Nanchang, Jiangxi, 330063, China.
  • Yusi Peng
    School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, Anhui, China.
  • Lei Peng
    Department of Urology, The Second Clinical College, North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, China.
  • Weidong Chen
    School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230031, China.
  • Liang Yao
    Northwestern University, Chicago, IL.
  • Ling He
    Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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