Accurate measurement of spleen volume is essential for the diagnosis of splenomegaly. While Computed Tomography (CT) is among the most reliable imaging modalities for this task, manual segmentation of the spleen is labor-intensive and impractical for...
Lipid nanoparticles (LNPs) are a promising nonviral delivery system for gene-editing proteins, but optimal formulations remain underexplored. Unlike messenger RNA-based approaches, ribonucleoprotein delivery enables immediate genome editing without r...
Surgical and radiologic anatomy : SRA
Sep 27, 2025
PURPOSE: In recent years, artificial intelligence has made significant advances in medical illustration, paralleling progress in many other fields. These tools provide an efficient and cost-effective approach to creating custom illustrations and rapi...
Messenger RNA (mRNA) therapeutics hold significant potential across a wide range of medical applications. LNPs are the most clinically advanced mRNA delivery vehicles, but challenges such as off-target effects and liver accumulation limit their broad...
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a significant risk factor for liver cancer and cardiovascular diseases, imposing substantial social and economic burdens. Computed tomography (CT) scans are crucial for diagnosing NAFLD and ass...
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of transcrip...
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are criti...
American journal of physiology. Cell physiology
Apr 18, 2025
As the largest secondary lymphoid organ, the spleen plays a crucial role in initiating and sustaining immune responses against blood-borne pathogens through antigen capture and delivery. It is innervated by both autonomic and sensory nerves, which al...
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...
Journal of cancer research and clinical oncology
Feb 3, 2025
OBJECTIVE: The objective of this study is to develop an automated method for segmenting spleen computed tomography (CT) images using a deep learning model. This approach is intended to address the limitations of manual segmentation, which is known to...
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