Predicting Early-Onset Colorectal Cancer in Individuals Below Screening Age Using Machine Learning and Real-World Data: Case Control Study.

Journal: JMIR cancer
Published Date: Jun 19, 2025

Abstract

BACKGROUND: Colorectal cancer is now the leading cause of cancer-related deaths among young Americans. Accurate early prediction and a thorough understanding of the risk factors for early-onset colorectal cancer (EOCRC) are vital for effective prevention and treatment, particularly for patients below the recommended screening age.

Authors

  • Chengkun Sun
    Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, 1889 Museum Road, Office 7020, Gainesville, FL, 32611, United States, 1 3526279467.
  • Erin Mobley
    University of Florida Health Cancer Center, University of Florida, Gainesville, FL, United States.
  • Michael Quillen
    Department of Medicine, University of Florida, Gainesville, FL, United States.
  • Max Parker
    Department of Medicine, University of Florida, Gainesville, FL, United States.
  • Meghan Daly
    Department of Surgery, University of Florida, Jacksonville, FL, United States.
  • Rui Wang
    Department of Clinical Laboratory Medicine Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China.
  • Isabela Visintin
    Department of Surgery, University of Florida, Jacksonville, FL, United States.
  • Ziad Awad
    Department of Surgery, University of Florida, Jacksonville, FL, United States.
  • Jennifer Fishe
    Department of Emergency Medicine, University of Florida, Jacksonville, FL, United States.
  • Alexander Parker
    Office of Research Affairs, University of Florida, College of Medicine, Jacksonville, Florida.
  • Thomas George
    University of Florida Health Cancer Center (UFHCC), Gainesville, FL 32610, USA.
  • Jiang Bian
    Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
  • Jie Xu
    Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310000, China.

Keywords

External Resources

Popular Topics
Recent Journals