Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis.

Journal: Journal of affective disorders
Published Date: Mar 11, 2025

Abstract

BACKGROUND: Major Depressive Disorder (MDD) and Bipolar Disorder (BD) exhibit overlapping depressive symptoms, complicating their differentiation in clinical practice. Traditional neuroimaging studies have focused on specific regions of interest, but few have employed whole-brain analyses like regional homogeneity (ReHo). This study aims to differentiate MDD from BD by identifying key brain regions with abnormal ReHo and using advanced machine learning techniques to improve diagnostic accuracy.

Authors

  • Weijian Han
    Qingdao Mental Health Center, Qingdao 266034, Shandong, China.
  • Yousong Su
    Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai 200030, China.
  • Xiangwen Wang
    College of Computer Science and Engineering, Northwest Normal University, Lanzhou, 730070, People's Republic of China.
  • Tao Yang
    The First Clinical Medical College, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
  • Guoqing Zhao
    Department of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, 250061, Shandong, China.
  • Ruizhi Mao
    Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
  • Na Zhu
    Department of Center of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Rubai Zhou
    Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai 200030, China.
  • Xing Wang
    Department of Neurosis and Psychosomatic Diseases, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China.
  • Yun Wang
    Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
  • Daihui Peng
    Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zuowei Wang
    Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai 200083, China.
  • Yiru Fang
    Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, China; Shanghai Key Laboratory of Psychotic disorders, Shanghai 201108, China. Electronic address: yirufang@aliyun.com.
  • Jun Chen
    Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ping Sun
    Department of Pathology, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.

Keywords

External Resources

Popular Topics
Recent Journals