Novel Transcriptomic Signatures in Fibrostenotic Crohn's Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets.

Journal: Inflammatory bowel diseases
Published Date:

Abstract

BACKGROUND: Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biological and cellular mechanisms underlying intestinal fibrosis.

Authors

  • Animesh Acharjee
    College of Medicine and Health, School of Medical Sciences, Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
  • Uday Shivaji
    Gastroenterology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Giovanni Santacroce
    APC Microbiome Ireland, College of Medicine and Health, University College Cork, Cork, T12 YT20, Ireland.
  • Sarah Akiror
    Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.
  • Louisa Jeffery
    Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Csilla Varnai
    Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Gary Reynolds
    Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.
  • Davide Zardo
    Department of Pathology, San Bortolo Hospital, Vicenza, Italy.
  • Snehali Majumder
    APC Microbiome Ireland, College of Medicine and Health, University College Cork (UCC), Cork, Ireland.
  • Asma Amamou
    APC Microbiome Ireland, College of Medicine and Health, University College Cork, Cork, Ireland.
  • Georgios V Gkoutos
    Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdom; MRC Health Data Research UK (HDR UK), London, United Kingdom; NIHR Experimental Cancer Medicine Centre, Birmingham, United Kingdom; NIHR Biomedical Research Centre, University Hospital Birmingham, Birmingham, United Kingdom.
  • Marietta Iacucci
    National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK.
  • Subrata Ghosh
    Professor of Medicine and Gastroenterology, Director, Institute of Translational Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TH, UK.