Clinical Decision Support for Septic Shock in the Emergency Department: A Cluster Randomized Trial.

Journal: Pediatrics
Published Date: Jul 1, 2025

Abstract

BACKGROUND AND OBJECTIVES: Delays in septic shock diagnosis cause preventable mortality in children. Evidence is limited around early recognition strategies. The hypothesis was that clinical decision support (CDS) based on machine-learning predictive models would increase the proportion of children receiving septic shock treatment prior to shock onset.

Authors

  • Halden F Scott
    Section of Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
  • Carter J Sevick
    Adult and Child Center for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
  • Kathryn L Colborn
    University of Colorado Anschutz Medical Campus, Colorado School of Public Health, Department of Biostatistics and Informatics, Aurora, CO, USA. Electronic address: kathryn.colborn@CUAnschutz.edu.
  • Sara J Deakyne Davies
    Research Informatics and Data Science, Children's Hospital Colorado, Aurora, Colorado.
  • Christopher H Greer
    Precision Medicine Institute, Children's Hospital Colorado, Aurora, Colorado.
  • Ashley Dafoe
    Adult and Child Center for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
  • Brooke Dorsey Holliman
    Adult and Child Center for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
  • Lalit Bajaj
    Section of Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
  • Sarah K Schmidt
    Section of Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
  • Allison Kempe
    Adult and Child Center for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.

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