Real-world faricimab switch in France: artificial intelligence-based detection of changes in exudative signs in difficult-to-treat neovascular age-related macular degeneration.

Journal: BMJ open ophthalmology
Published Date: Jun 23, 2025

Abstract

PURPOSE: Some patients with neovascular age-related macular degeneration (nAMD) have persistent signs of exudation under treatment with intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. We examined the real-world anatomical responses among patients with suboptimal response and switched to faricimab using artificial intelligence (AI)-based retinal fluid quantification.

Authors

  • Vincent Gualino
    Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, Toulouse, France.
  • Charles Sohier
    Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, Toulouse, France.
  • Maxime Sibert
    Ophthalmology Department, Dijon University Hospital, Dijon, France.
  • Ali Erginay
    Service d' Ophtalmologie, Hôpital Lariboisière, APHP, Paris, France.
  • Fanny Varenne
    Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, Toulouse, France.
  • Jacqueline Butterworth
    Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, Toulouse, France.
  • Aude Couturier
    Ophthalmology Department, Lariboisière Hospital, Paris University Hospital, Paris, France.
  • Pierre-Henry Gabrielle
    Ophthalmology Department, Dijon University Hospital, Dijon, France.
  • Vincent Soler
    Department of Ophthalmology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
  • Catherine Creuzot-Garcher
    Ophthalmology Department, Dijon University Hospital, Dijon, France.

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