Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity.

Journal: Diabetologia
Published Date: Apr 30, 2025

Abstract

AIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but thrombotic pathways in type 1 diabetes are only partially understood and the role of platelets is incompletely studied. We hypothesised that platelets from individuals with type 1 diabetes exhibit platelet hyperactivity due to both increased propensity for activation and diminished sensitivity to inhibition, with an amplified maladaptive phenotype in those with insulin resistance.

Authors

  • Rebecca C Sagar
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK. medrsag@leeds.ac.uk.
  • Daisie M Yates
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
  • Sam M Pearson
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
  • Noppadol Kietsiriroje
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
  • Matthew S Hindle
    Centre for Biomedical Science Research, School of Health, Leeds Beckett University, Leeds, UK.
  • Lih T Cheah
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
  • Beth A Webb
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
  • Ramzi A Ajjan
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
  • Khalid M Naseem
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

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