AIMC Topic: Platelet Activation
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Optimization of hemocompatibility metrics in ventricular assist device design using machine learning and CFD-based response surface analysis.
The International journal of artificial organs
Jun 6, 2025
Ventricular assist devices (VADs) are essential for end-stage heart failure patients, but their design must balance hydraulic efficiency and hemocompatibility to minimize blood damage. This study presents a multi-objective optimization framework inte...
Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity.
Diabetologia
Apr 30, 2025
AIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but thrombotic pathways in type 1 diabetes ...
Deciphering Abnormal Platelet Subpopulations in COVID-19, Sepsis and Systemic Lupus Erythematosus through Machine Learning and Single-Cell Transcriptomics.
International journal of molecular sciences
May 29, 2024
This study focuses on understanding the transcriptional heterogeneity of activated platelets and its impact on diseases such as sepsis, COVID-19, and systemic lupus erythematosus (SLE). Recognizing the limited knowledge in this area, our research aim...
Using DeepLab v3 + -based semantic segmentation to evaluate platelet activation.
Medical & biological engineering & computing
Apr 29, 2022
This research used DeepLab v3 + -based semantic segmentation to automatically evaluate the platelet activation process and count the number of platelets from scanning electron microscopy (SEM) images. Current activated platelet recognition and counti...
Fully automated platelet differential interference contrast image analysis via deep learning.
Scientific reports
Mar 17, 2022
Platelets mediate arterial thrombosis, a leading cause of myocardial infarction and stroke. During injury, platelets adhere and spread over exposed subendothelial matrix substrates of the damaged blood vessel wall. The mechanisms which govern platele...
Intelligent classification of platelet aggregates by agonist type.
eLife
May 12, 2020
Platelets are anucleate cells in blood whose principal function is to stop bleeding by forming aggregates for hemostatic reactions. In addition to their participation in physiological hemostasis, platelet aggregates are also involved in pathological ...
Prediction of high on-treatment platelet reactivity in clopidogrel-treated patients with acute coronary syndromes.
International journal of cardiology
Mar 18, 2017
BACKGROUND: About 40% of clopidogrel-treated patients display high platelet reactivity (HPR). Alternative treatments of HPR patients, identified by platelet function tests, failed to improve their clinical outcomes in large randomized clinical trials...
[Innovative activated platelet detection technology by artificial intelligence].
[Rinsho ketsueki] The Japanese journal of clinical hematology
Jan 1, 2020
Although antiplatelet drugs are widely used for the prevention and treatment of atherothrombosis, clinical tests capable of evaluating their efficacy have not been established. Focusing on platelet aggregates in blood, we announced the world's first ...
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