Transcriptomic analyses of human brains with Alzheimer's disease identified dysregulated epilepsy-causing genes.

Journal: Epilepsy & behavior : E&B
Published Date: Apr 17, 2025

Abstract

BACKGROUND & OBJECTIVE: Alzheimer's Disease (AD) patients at multiple stages of disease progression have a high prevalence of seizures. However, whether AD and epilepsy share pathophysiological changes remains poorly defined. In this study, we leveraged high-throughput transcriptomic data from sporadic AD cases at different stages of cognitive impairment across multiple independent cohorts and brain regions to examine the role of epilepsy-causing genes.

Authors

  • Abdallah M Eteleeb
    Department of Psychiatry, Washington University, Saint Louis, St. Louis, MO, United States of America; The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University, St. Louis, MO, United States of America.
  • Suélen Santos Alves
    Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Brazil.
  • Stephanie Buss
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Mouhsin Shafi
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
  • Daniel Press
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
  • Norberto Garcia-Cairasco
    Physiology Department and Neuroscience and Behavioral Sciences Department, Ribeirão Preto Medical School, University of São Paulo, Brazil. Electronic address: ngcairas@usp.br.
  • Bruno A Benitez
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address: bbenitez@bidmc.harvard.edu.

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