Increased Global and Regional Connectivity in Propofol-induced Unconsciousness: Human Intracranial Electroencephalography Study.

Journal: Anesthesiology
Published Date: Apr 3, 2025

Abstract

BACKGROUND: The conscious state is maintained through intact communication between brain regions. However, studies on global and regional connectivity changes in unconscious state have been inconsistent. These inconsistencies could arise from unclear definition of unconsciousness, spatial and temporal limitations of neuroimaging modalities, and estimating only single connectivity measure. This study investigated global and regional changes in amplitude and phase-based functional connectivity in propofol-induced unconsciousness, which is widely recognized as unconsciousness.

Authors

  • Mikyung Choe
    Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
  • Yunhee Choi
    Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.
  • Jii Kwon
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
  • Hee-Pyoung Park
  • Seung-Hyun Jin
    Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
  • June Sic Kim
    Sensory Organ Research Institute, Seoul National University, Seoul, 151-742, Korea. jskim@meg.re.kr.
  • Seokhyun Lee
    School of Psychology, Korea University, Seoul, Republic of Korea.
  • Chun Kee Chung
    Interdisciplinary Program in Neuroscience, Graduate School, Seoul National University, Seoul, 151-742, Korea. chungc@snu.ac.kr.

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