Dynamic glucose enhanced imaging using direct water saturation.

Journal: Magnetic resonance in medicine
Published Date: Mar 17, 2025

Abstract

PURPOSE: Dynamic glucose enhanced (DGE) MRI studies employ CEST or spin lock (CESL) to study glucose uptake. Currently, these methods are hampered by low effect size and sensitivity to motion. To overcome this, we propose to utilize exchange-based linewidth (LW) broadening of the direct water saturation (DS) curve of the water saturation spectrum (Z-spectrum) during and after glucose infusion (DS-DGE MRI).

Authors

  • Linda Knutsson
    Department of Medical Radiation Physics, Lund University, Lund, Sweden.
  • Nirbhay N Yadav
    The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sajad Mohammed Ali
    Department of Medical Radiation Physics, Lund University, Lund, Sweden.
  • David Olayinka Kamson
    Department of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Eleni Demetriou
    F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
  • Anina Seidemo
    Diagnostic Radiology, Department of Clinical Sciences, Lund University, Lund, Sweden.
  • Lindsay Blair
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Doris D Lin
    The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
  • John Laterra
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Peter C M van Zijl
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA.

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