Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.

Journal: Cellular signalling
Published Date:

Abstract

OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute pancreatitis (AP) risk assessment.

Authors

  • Jian Chen
    School of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
  • Fu Li
    CPFL Energia, Campinas, São Paulo 13087-397, Brazil.
  • Wang-Sheng Luo
    Department of Cardiology, the First Affiliated Hospital of University of South China, Hengyang, China.
  • Mei-Fang Zhu
    Research Studio of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
  • Neng-Jiang Zhao
    Research Studio of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
  • Zhi-Hai Zhang
    Research Studio of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
  • Ya-Feng Chen
    Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
  • Dian-Xu Feng
    Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China. Electronic address: fdianxu@163.com.
  • Shu-Yu Yang
    Research Studio of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China. Electronic address: xmyangshuyu@126.com.
  • Wen-Jie Sun
    Research Studio of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China; Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China; Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: wenjiesun333@163.com.