Diastolic Versus Systolic or Mean Intraoperative Hypotension as Predictive of Perioperative Myocardial Injury in a White-Box Machine-Learning Model.

Journal: Anesthesia and analgesia
Published Date: Feb 20, 2025

Abstract

BACKGROUND: Intraoperative hypotension (IOH) and tachycardia are associated with perioperative myocardial injury (PMI), and thereby increased postoperative mortality. Patients undergoing vascular surgery are specifically at risk of developing cardiac complications. This study aimed to explore the association between different thresholds for IOH and tachycardia, and PMI. It also aimed to explore which threshold for IOH and tachycardia best predicts PMI.

Authors

  • Arman Valadkhani
    From Department of Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.
  • Anil Gupta
    From Department of Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.
  • Giordano Cauli
    Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology.
  • Johan L Nordström
    From Department of Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.
  • Ayda Rohi
    From Department of Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.
  • Panos Tufexis
    Department of Pharmacology and Physiology, Karolinska Institutet, Stockholm, Sweden.
  • Caroline Hällsjö Sander
    Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, 171 76, Solna, Stockholm, Sweden. caroline.hallsjo-sander@karolinska.se.
  • Martin Jacobsson
    Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden.
  • Max Bell
    From Department of Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.

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