Preoperative prediction of post hepatectomy liver failure after surgery for hepatocellular carcinoma on CT-scan by machine learning and radiomics analyses.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Published Date:

Abstract

INTRODUCTION: No instruments are available to predict preoperatively the risk of posthepatectomy liver failure (PHLF) in HCC patients. The aim was to predict the occurrence of PHLF preoperatively by radiomics and clinical data through machine-learning algorithms.

Authors

  • Simone Famularo
    Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; IRCAD, Research Institute Against Cancer of the Digestive System, 1 Place de l'Hôpital, Strasbourg, 67091, France. Electronic address: simone.famularo@gmail.com.
  • Cesare Maino
    Department of Radiology, Fondazione IRCCS San Gerardo dei Tintori, Monza 20900, Italy.
  • Flavio Milana
    Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Francesco Ardito
    Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
  • Gianluca Rompianesi
    Division of Hepato-Biliary-Pancreatic, Minimally Invasive and Robotic Surgery and Kidney Transplantation, Department of Clinical Medicine and Surgery, Federico II University Hospital, via S. Pansini n. 5, Naples, Italy. gianlucarompianesi@gmail.com.
  • Cristina Ciulli
    School of Medicine and Surgery, University of Milan-Bicocca, Department of Surgery, San Gerardo Hospital, Monza, Italy.
  • Simone Conci
    Department of Surgery, University of Verona, Verona, Italy.
  • Anna Gallotti
    Unit of General Surgery 1, University of Pavia and Foundation IRCCS Policlinico San Matteo, Pavia, Italy.
  • Giuliano La Barba
    General and Oncologic Surgery, Morgagni-Pierantoni Hospital, Department of Medical and Surgical Sciences, University of Bologna Forlì, Italy.
  • Maurizio Romano
    Department of Surgical, Oncological and Gastroenterological Science (DISCOG), University of Padua, Hepatobiliary and Pancreatic Surgery Unit, Treviso Hospital, Italy.
  • Michela De Angelis
    Department of General Surgery, Ospedale Carlo Poma, Mantua, Italy.
  • Stefan Patauner
    Department of General and Pediatric Surgery, Bolzano Central Hospital, Bolzano, Italy.
  • Camilla Penzo
    Pole d'Expertise de la Regulation Numérique (PEReN), Paris, France.
  • Agostino Maria De Rose
    Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
  • Jacques Marescaux
  • Michele Diana
  • Davide Ippolito
    Department of Diagnostic and Interventional Radiology, San Gerardo Hospital, Monza, Italy.
  • Antonio Frena
    Department of General and Pediatric Surgery, Bolzano Central Hospital, Bolzano, Italy.
  • Luigi Boccia
    Department of General Surgery, Ospedale Carlo Poma, Mantua, Italy.
  • Giacomo Zanus
    Department of Surgical, Oncological and Gastroenterological Science (DISCOG), University of Padua, Hepatobiliary and Pancreatic Surgery Unit, Treviso Hospital, Italy.
  • Giorgio Ercolani
    Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Forlì, Italy.
  • Marcello Maestri
    Fondazione IRCCS Policlinico San Matteo, SC Chirurgia Generale 1, Pavia, Italy. Electronic address: m.maestri@smatteo.pv.it.
  • Gian Luca Grazi
    Division of Hepatobiliarypancreatic Unit, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.
  • Andrea Ruzzenente
    Department of Surgery, University of Verona, Verona, Italy.
  • Fabrizio Romano
    School of Medicine and Surgery, University of Milan-Bicocca, Department of Surgery, San Gerardo Hospital, Monza, Italy.
  • Roberto Ivan Troisi
  • Felice Giuliante
    Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
  • Matteo Donadon
    Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy; Department of General Surgery, University Maggiore Hospital Della Carità, Novara, Italy.
  • Guido Torzilli
    Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.