Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner.

Journal: BMC medicine
Published Date:

Abstract

BACKGROUND: In humans, uric acid is a product of purine metabolism that impacts the vascular system. In addition to effects on arterial vascular tone, associations between serum uric acid concentrations-even in the physiological range-and arterial hypertension and vascular-mediated end-organ damage due to an impact on vascular stiffness have been postulated.

Authors

  • Oliver Thews
    Julius-Bernstein-Institut für Physiologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany.
  • Thomas Schmid
    AG Digitale Forschungsmethoden in der Medizin, Martin-Luther-Universität Halle-Wittenberg, Medizinische Fakultät, Halle (Saale), Germany.
  • Alexander Kluttig
    Studienzentrumder, NAKO Gesundheitsstudie , Halle (Saale), Germany.
  • Andreas Wienke
    Institute of Medical Epidemiology, Biometry, and Informatics, Profile Center Health Sciences, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
  • Melanie Zinkhan
    Biobank der Universitätsmedizin Halle, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany.
  • Wolfgang Ahrens
    Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS , Bremen, Germany.
  • Till Bärnighausen
    Heidelberg Institute of Global Health, Heidelberg, Germany.
  • Hermann Brenner
    German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Stefanie Castell
    Department for Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Germany.
  • Berit Lange
    Department of Epidemiology, Helmholtz-Centre for Infection Research, Braunschweig, Germany.
  • Wolfgang Lieb
    Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Karin Halina Greiser
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
  • Marcus Dörr
    Department of Internal Medicine B, Cardiology, Angiology & Pneumology, University Medicine of Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
  • Lilian Krist
    Institute of Social Medicine, Epidemiology and Health Economics of the Charité, Berlin, Germany.
  • Stefan N Willich
    Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Volker Harth
    Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Nadia Obi
    Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Michael Leitzmann
    Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
  • Annette Peters
    Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Börge Schmidt
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
  • Matthias B Schulze
    Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Henry Völzke
    Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Matthias Nauck
    DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
  • Stephanie Zylla
    German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
  • Anke Hannemann
    German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
  • Tobias Pischon
    Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
  • Ilais Moreno Velásquez
    Max-Delbrueck-Center for Molecular Medicinein the, Molecular Epidemiology Research Group , Helmholtz Association (MDC), Berlin, Germany.
  • Matthias Girndt
    Universitätsklinik für Innere Medizin II, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany.
  • Claudia Grossmann
    Julius-Bernstein-Institut für Physiologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany.
  • Michael Gekle
    Julius-Bernstein-Institut für Physiologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany. michael.gekle@medizin.uni-halle.de.