Assessment of established prognostic factors and artificial intelligence-based evaluation of tumor-infiltrating lymphocytes in oral tongue squamous cell carcinoma.

Journal: Oral oncology
Published Date:

Abstract

BACKGROUND: Traditional risk assessment for tongue cancer relies on clinicopathological parameters. Although tumor-infiltrating lymphocytes (TILs) are promising prognostic markers, their evaluation lacks standardization. This study aimed to validate established prognostic factors and introduce an artificial intelligence (AI)-based TIL assessment method.

Authors

  • Jongwon Lee
    Center for Single Atom-based Semiconductor Device and Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
  • Ming Fan
    Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, Hangzhou 310018, China.
  • Donghyeok Jo
    Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.
  • Jungbok Lee
    Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
  • Joon Seon Song
    Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Hee Jin Lee
    Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea.
  • Seung-Ho Choi
    Departments of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: shchoi@amc.seoul.kr.
  • Soon Yuhl Nam
    Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Yoon Se Lee
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Dong-Joo Kim
    Department of Brain and Cognitive Engineering, Korea University.
  • Kyung-Ja Cho
    Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: kjc@amc.seoul.kr.