Psoas muscle CT radiomics-based machine learning models to predict response to infliximab in patients with Crohn's disease.

Journal: Annals of medicine
Published Date: Jul 5, 2025

Abstract

BACKGROUND: Crohn's disease (CD) is a chronic inflammatory bowel disease, with infliximab (IFX) commonly used for treatment. However, no clinically applicable model currently exists to predict the response of patients with CD to IFX therapy. Given the strong association between sarcopenia and IFX treatment outcomes, this study developed computerized tomography radiomics-based machine learning (ML) models, utilizing psoas muscle volume as a proxy for skeletal muscle mass, to predict the response of patients with CD to IFX therapy.

Authors

  • Zhuoyan Chen
    Department of Gastroenterology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, China.
  • Weimin Cai
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Yuanhang He
    Department of Gastroenterology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Tianhao Mei
    Department of Gastroenterology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yuxuan Zhang
    School of Electrical Engineering, Yanshan University, 438 Hebei Avenue, Qinhuangdao 066004, China. Electronic address: 1535937433@qq.com.
  • Shiyu Li
    Department of Biomedical Engineering, ShenZhen University, ShenZhen, 518000, China.
  • Yiwen Hong
    Department of Gastroenterology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yuhao Chen
    Department of Industrial and Systems Engineering, University of Florida, Gainesville, FL, 32611, USA.
  • Huiya Ying
    Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, P.R. China.
  • Yuan Zeng
    Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, P.R. China.
  • Fujun Yu
    Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, P.R. China. yufujun@wmu.edu.cn.

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